UC-NGI-GR-III

From EGI Knowledge Base

Use Case title: Advancing Clinico-Genomic Clinical Trials on Cancer (ACGT)

Short description: The objective of ACGT is the provision of a unified technological infrastructure which will facilitate the seamless and secure access and analysis, of multi-level clinico-genomic data enriched with high-performing knowledge discovery operations and services. ACGT will deliver a biomedical GRID infrastructure able to: manage distributed databases where clinical applications, decision support and knowledge discovery operations would access information, data and computational resources scattered over geographically dispersed databases and code-repositories - the data-GRID. Special effort will be devoted for the GRID-enabling of the provisioned data mining components and knowledge discovery operations. Besides the computational empowerment, the provisioned ACGT GRID infrastructure will be also tuned in order to support the seamless aspects in data management and processing, thus meeting the needs of a knowledge-GRID. Currently ACGT mainly focuses on the following generic “applications”:

• The multicentric clinical trial on Breast Cancer
• The clinical trial on Paediatric nephroblastoma (Wilms tumor)
• The In Silico modeling and simulation of tumor growth & response to treatment
• The first two scenarios have some medium requirements for storage and bandwidth whereas the third one is mostly a computational task.

Actors involved: